Paola Dal Cin
نویسندگان
چکیده
Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer, more common in solid tumors than in hematologic malignancies. Double minute chromosomes are seen primarily in acute myeloid leukemia, with amplification of the MYC oncogene or, less frequently, the MLL transcription factor (Rayeroux and Campbell 2009). Both normal and abnormal karyotypes were reported together with dmin, and rarely with hsr. It is associated with a poor prognosis, rapid disease progression and short survival , however only in case reports and small series (Thomas et al, 2004, Receveur et al 2004).
منابع مشابه
The Molecular Signature of Mediastinal Large B-Cell Lymphoma Differs from that of other Diffuse Large B-cell Lymphomas and Shares Features with Classical Hodgkin’s Lymphoma
Prepublished online August 21, 2003; Nancy Lee Harris, Jon C Aster, Todd R Golub and Margaret A Shipp Salles, Francoise Berger, Wen Jing, Geraldine S Pinkus, Thomas Habermann, Riccardo Dalla-Favera, Paul Kurtin, Paola Dal Cin, Christine Ladd, Friedrich Feuerhake, Ricardo C T Aguiar, Sigui Li, Gilles Kerry J Savage, Stefano Monti, Jeffery L Kutok, Giorgio Cattoretti, Donna Neuberg, Laurence de L...
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